experimental validation – Communicable Diseases Research

Xuanfei Baidu Formula attenuates LPS-induced acute lung injury by inhibiting the NF-κB signaling pathway

Article

Published on 2023-01-302022-11-15
Journal: Journal of ethnopharmacology
[Category] 유전자 메커니즘, 진단,

Aerosolized Hydrogen Peroxide Decontamination of N95 Respirators, with Fit-Testing and Viral Inactivation, Demonstrates Feasibility for Reuse during the COVID-19 Pandemic

Article

Published on 2022-10-262022-11-15
Journal: mSphere
[Category] COVID19(2023년), SARS, 진단,

[키워드] absorbed acute respiratory syndrome aerosolized hydrogen peroxide Aerosols Bacterial baseline Biosafety Level 3 BSL3 Care Clinical use comparable coronavirus COVID-19 COVID-19 pandemic coxsackievirus Critical CURIS decontamination develop Disinfection effective Efficiency evaluated experimental validation External filtering facepiece (FFP) respirators (FFR) filtration fit-testing greater Health Health care worker herpes simplex HSV-1 hydrogen hydrogen peroxide inactivation include indicated limit limitation Multiple N95 respirator N95 respirators occupational pandemic pathogen peroxide Personal protective equipment Protective provided Quantitative Research Respirator respirators respiratory droplet Result reuse Safe Safety SARS-CoV-2 SARS-CoV2 spores Sterilization These data transmitted Treatment viral inactivation virologic testing virus virus virus. while
[DOI] 10.1128/msphere.00303-22 PMC 바로가기

Deciphering SARS CoV-2-associated pathways from RNA sequencing data of COVID-19-infected A549 cells and potential therapeutics using in silico methods

Article

Published on 2022-09-022022-11-16
Journal: Medicine
[Category] SARS, 유전자 메커니즘,

[키워드] A549 cell activated Activation acute respiratory syndrome addition Analysis Atypical candidate caused characterized CLC complications CoV COVID COVID-19 COVID-19 infection cytokine deaths DEGs Determining differentially expressed gene disease drug effective experimental validation Gene Expression Omnibus gene signatures Genomics GEO GSE147507 human-to-human transmission identify IFNβ IL-17 IL-1β Illumina in silico In silico method influenza A Interaction interferon beta interferon regulatory factor IRF3 IRF9 JQ1 knowledge mechanism Methylprednisolone mock-treated pathology pathway Pneumonia Prednisolone Quality control receptors RNA RNA sequencing RNA sequencing data SARS CoV-2 signaling pathway signaling pathways small molecule STAT2 the Coronaviridae the disease therapy Transcription Treatment underlying disease upstream Viral protein virus infection was used with COVID-19 Wuhan, China
[DOI] 10.1097/MD.0000000000029554 PMC 바로가기

An in silico approach to study the role of epitope order in the multi-epitope-based peptide (MEBP) vaccine design

다중 에피토프 기반 펩타이드(MEBP) 백신 설계에서 에피토프 순서의 역할을 연구하기 위한 in silico 접근법

Article

Published on 2022-07-222022-09-11
Journal: Scientific Reports
[Category] COVID19(2023년), SARS, 변종,

The IDentif.AI-x pandemic readiness platform: Rapid prioritization of optimized COVID-19 combination therapy regimens

Research

Published on 2022-06-302022-10-05
Journal: NPJ Digital Medicine
[Category] 신약개발, 임상, 치료법, 치료제,

Commentary on “Poor evidence for host-dependent regular RNA editing in the transcriptome of SARS-CoV-2”

"SARS-CoV-2의 전사체에서 숙주 의존적 정규 RNA 편집에 대한 불충분한 증거"에 대한 논평

Article

Published on 2022-05-012022-09-11
Journal: Journal of applied genetics
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

Computer-Based Immunoinformatic Analysis to Predict Candidate T-Cell Epitopes for SARS-CoV-2 Vaccine Design

SARS-CoV-2 백신 디자인을 위한 후보 T-세포 에피토프를 예측하기 위한 컴퓨터 기반 면역정보 분석

Article

Published on 2022-03-302022-09-11
Journal: Frontiers in Immunology
[Category] SARS, 변종, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity allele Antigen B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 binding free energy Brazil candidate caused change Chinese clinical trial collected coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 effective epitope Epitopes evaluated Evidence experimental validation free energy HLA HLA-A human leukocyte antigen immune mechanism IMPROVE Inclusion India less leukocyte molecular molecular docking mutate mutated Mutation neutralizing antibody New outbreak overlapping P.1 pandemic peptide peptides predict predicted Prevalence problem residue S protein S-protein SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 virus infection selected severe acute respiratory syndrome Coronavirus South Africa Spike protein strain T-cell T-cell epitopes therapy United Kingdom Vaccine Vaccine design Vaccine development vaccine. Vaccines virus virus virus genomes virus infection was used
[DOI] 10.3389/fimmu.2022.847617 PMC 바로가기 [Article Type] Article

Efficient Identification of Anti-SARS-CoV-2 Compounds Using Chemical Structure- and Biological Activity-Based Modeling

화학 구조 및 생물학적 활성 기반 모델링을 사용한 Anti-SARS-CoV-2 화합물의 효율적인 식별

Article

Published on 2022-03-242022-09-11
Journal: Journal of medicinal chemistry
[Category] SARS, 신약개발, 치료제,

Plant-Derived Antiviral Compounds as Potential Entry Inhibitors against Spike Protein of SARS-CoV-2 Wild-Type and Delta Variant: An Integrative in SilicoApproach

SARS-CoV-2 야생형 및 델타 변이체의 스파이크 단백질에 대한 잠재적 진입 억제제로서의 식물 유래 항바이러스 화합물: SilicoApproach의 통합

Article

Published on 2022-03-082022-09-11
Journal: Molecules
[Category] SARS, 변종, 신약개발, 진단, 치료제,

[키워드] antagonists Antiviral Antiviral agents antiviral drug antiviral drugs approach approaches binding affinities binding affinity binding energy binding free energies binding free energy binding interaction carried complexes Complexes Compound compounds controls Corilagin country COVID-19 COVID-19 infection Delta delta variant develop docking Efficacy exhibited experimental validation explained FIVE free energies glycoprotein greater H-bonds hydrogen hydrophobic interaction hydrophobic interactions Hypericin in silico India lead Ligand ligands Lupeol molecular molecular docking molecular dynamics molecular dynamics and simulations Molecular modeling mutated phytochemical compounds plant compound Potential Protein Research resulting RMSD RMSF S protein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant second wave selected several variant several variants spike spike glycoprotein Spike protein stability target proteins therapeutic intervention Transmissibility Vaccine Virtual screening virtual screening. virulence was performed while wild-type wild-type SARS-CoV-2
[DOI] 10.3390/molecules27061773 PMC 바로가기 [Article Type] Article

Structural Comparison and Drug Screening of Spike Proteins of Ten SARS-CoV-2 Variants

Research Article

Published on 2022-02-012022-10-29
Journal: Research
[Category] COVID-19,

[키워드] ACE2-RBD acute respiratory syndrome Analysis anti-SARS-CoV-2 antibody Beta Cell Characteristics Cluster Clustering analysis complexes Compound contribute coronavirus Delta delta variant drug Endemic Epsilon experimental validation feature Gamma immune evasion in vitro in vivo induce Infection Iota knowledge Lambda Medicines Mutation NTD pandemic pathophysiology potential therapy predicted Protein protein sequence provided RBD SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants Screening similarity spike Spike protein Strains Structure structures the binding affinity the epidemic the SARS-CoV-2 the spike protein understanding unique variant variants Virtual screening ZINC database
[DOI] 10.34133/2022/9781758 PMC 바로가기 [Article Type] Research Article